Palladia® (Toceranib Phosphate) - Targeted Anti-Cancer Therapy for Dogs & Cats
Palladia® (Toceranib Phosphate) - Targeted Anti-Cancer Therapy for Dogs & Cats
Palladia® (Toceranib Phosphate) - Targeted Anti-Cancer Therapy for Dogs & Cats
Palladia® (Toceranib Phosphate) - Targeted Anti-Cancer Therapy for Dogs & Cats

Palladia® (Toceranib Phosphate) - Targeted Anti-Cancer Therapy for Dogs & Cats

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Palladia® (Toceranib Phosphate) is a targeted tyrosine kinase inhibitor (TKI) developed for the treatment of cancer in companion animals. It is FDA-approved for canine mast cell tumors and is increasingly used off-label in cats for various neoplastic and proliferative diseases under veterinary guidance.

By selectively blocking tumor growth signals and inhibiting tumor blood vessel formation, Palladia offers a modern, targeted approach to oncology treatment while minimizing damage to healthy tissues.

This medication is widely used in veterinary oncology clinics worldwide and is valued for its oral administration, targeted mechanism, and proven clinical efficacy.
⭐ Key Benefits

✅ FDA-approved for dogs with mast cell tumours

✅ Targeted cancer therapy (Tyrosine Kinase Inhibitor)

✅ Inhibits tumor cell proliferation and angiogenesis

✅ Used off-label in cats for selected cancers

✅ Oral tablets for convenient at-home administration

✅ Can be combined with other oncology protocols under veterinary care
💊 Usage & Dosage

Dogs

Typical dose:
3.25 mg/kg orally every other day

Tablets should be given with or without food

Regular blood tests and monitoring are required

Cats

Typical reported dose range:
2.5-3.25 mg/kg orally every other day

Many veterinarians start at lower doses to improve tolerance

Close monitoring of blood counts, liver, and kidney values is essential
⚠️ Side Effects

Common

Decreased appetite

Vomiting or diarrhea

Lethargy

Weight loss

Less Common

Neutropenia or anemia

Gastrointestinal ulceration

Lameness

Delayed wound healing

Elevated liver enzymes

Serious (Rare)

Severe gastrointestinal bleeding

Protein-losing nephropathy

Pancreatitis

⚠️ Discontinue and consult a veterinarian immediately if severe or persistent side effects occur.
❗ Importance

❌ Not for use in pregnant or breeding animals

❌ Handle tablets with gloves (cytotoxic drug)

❌ Avoid exposure for immunocompromised individuals

✔️ Routine blood work is strongly recommended during treatment
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