Vetoryl® Trilostane Capsules for Dogs

FDA-Approved Treatment for Cushing's Disease in Dogs

If your dog is drinking excessively, urinating frequently, panting without reason, or developing a pot-bellied appearance, Cushing's disease may be the cause. Vetoryl® (Trilostane) is the only FDA-approved oral medication for treating hyperadrenocorticism (Cushing's disease) in dogs — effectively reducing cortisol overproduction, controlling symptoms, and protecting your dog from serious long-term complications.

How Vetoryl® Works

Trilostane is a competitive inhibitor of 3β-hydroxysteroid dehydrogenase — a key enzyme in the adrenal steroid synthesis pathway. By blocking this enzyme, Vetoryl® reduces the production of cortisol and other adrenal steroids, bringing cortisol levels back into a healthy range and resolving the clinical signs of Cushing's disease.

Signs of Cushing's Disease Vetoryl® Addresses

• Excessive thirst & urination (PU/PD) — one of the most common presenting signs
• Pot-bellied appearance — caused by muscle wasting and fat redistribution
• Hair loss & poor coat condition — bilateral symmetrical alopecia
• Increased appetite & weight gain — driven by elevated cortisol
• Panting & lethargy — reduced exercise tolerance and energy
• Skin changes — thinning, calcinosis cutis, and susceptibility to infections

Why Choose Vetoryl®?

• FDA-approved — the only trilostane product with FDA approval for canine Cushing's disease
• Effective for both forms — treats pituitary-dependent and adrenal-dependent hyperadrenocorticism
• Prevents serious complications — uncontrolled Cushing's can lead to diabetes, hypertension, and life-threatening infections
• Improves quality of life — most dogs show significant symptom improvement within weeks of starting treatment
• Wide dose range — available in 5 strengths for precise, weight-based dosing

Available Strengths

• 5 mg × 30 capsules
• 10 mg × 30 capsules
• 30 mg × 30 capsules
• 60 mg × 30 capsules
• 120 mg × 30 capsules

Recommended Use

Vetoryl® is a prescription medication requiring careful veterinary monitoring. ACTH stimulation testing is essential before starting treatment and at regular intervals during therapy to ensure cortisol levels are appropriately controlled. Administer with food. Do not adjust dose without veterinary guidance.